You've Heard of Rejuran. You've Heard of Profhilo. Now You Can't Decide.
If you've been researching injectable skin treatments in Korea, you've likely encountered Rejuran, Juvelook, and Profhilo — often described in similar terms: hydration, collagen stimulation, skin quality improvement.
So which is actually better? The honest answer: it depends on what your skin needs, because these work very differently.
The Key Ingredient in Each
Rejuran
Core ingredient: PN (Polynucleotide)
- Derived from salmon DNA
- Triggers skin cell regeneration and repair
- Strengthens skin barrier, reduces pore appearance
- Best for: skin repair, texture improvement, barrier restoration
Juvelook (and Juvelook Black)
Core ingredient: PDLLA microspheres + Hyaluronic acid
- PDLLA slowly releases bioactive molecules while breaking down
- Stimulates collagen and elastin production over time
- Combined effect of immediate hydration (HA) + long-term biostimulation (PDLLA)
- Best for: skin quality improvement with volume restoration
Our clinic also carries Lediesse (another PDLLA-based biostimulator, 900,000 KRW) for patients seeking a higher-concentration formulation.
Profhilo
Core ingredient: ultra-high concentration Hyaluronic acid (NASHA technology)
- Exceptionally high HA concentration (64mg per 2ml)
- Spreads through skin tissue as a bioremodeling agent
- Improves laxity, hydration, and overall skin quality
- Best for: dry, thin, or aging skin needing overall quality lift
Side-by-Side Comparison
| Rejuran | Juvelook Black | Profhilo | |
|---|---|---|---|
| Key ingredient | PN (polynucleotide) | PDLLA + HA | Ultra-high HA |
| Mechanism | Cellular repair | Collagen biostimulation | Tissue remodeling |
| Hydration effect | Moderate | Moderate | High |
| Collagen stimulation | Yes (indirect) | Yes (direct) | Yes (indirect) |
| Pore improvement | Yes | Limited | Limited |
| Ideal candidate | Damaged barrier, texture | Volume loss + quality | Dry, lax skin |
| Number of sessions | 3–4 sessions | 3–4 sessions | 2 sessions |
| Our clinic price (tax excl.) | 400,000 KRW (Black) | 600,000 KRW | N/A (not at our clinic) |
Rejuran vs Juvelook: The Most Common Comparison
Both are popular in Korea and often positioned as alternatives to each other. Here's how to think about it:
Choose Rejuran if:
- Your main concern is skin texture, enlarged pores, or skin that feels "thin" or damaged
- You want barrier repair and cellular-level renewal
- You're dealing with post-procedure recovery or sensitive skin
Choose Juvelook if:
- You want noticeable biostimulation with volume support
- Your skin has lost firmness and density (not just hydration)
- You want a longer-lasting structural improvement
Many patients actually receive both in a staged plan — Rejuran first to repair and prepare the skin, Juvelook for sustained regeneration afterward.
Rejuran vs Profhilo
Profhilo is popular in Europe and increasingly requested in Korea.
Profhilo's strength is its rapid, whole-tissue remodeling effect — particularly for lax, dry, or crepe-paper-texture skin. The ultra-high HA concentration distributes widely through the tissue and has a more pronounced laxity-addressing effect than Rejuran.
Rejuran's strength is more targeted cellular repair. If your issue is pore texture, post-inflammatory changes, or a compromised skin barrier, Rejuran's PN mechanism addresses this more directly than high-concentration HA.
Results and side effects may vary by individual. Please consult before deciding on treatment.
Still unsure which fits your goals? Message us on WhatsApp or LINE (ogana_mg) — a brief description of your main concern is usually enough to point you in the right direction.
Common Mistakes When Choosing a Skin Booster
Mistake 1: Choosing by name recognition alone Rejuran is well-known. Profhilo is trending. But neither is universally "the best" — it depends on your specific skin issue.
Mistake 2: Ignoring the importance of proper technique All three require careful injection technique. Juvelook in particular needs precise placement to avoid lumping. Always verify the practitioner is a qualified physician.
Mistake 3: Expecting results after one session All three typically require a course of 2–4 sessions for optimal results. One session is a starting point, not a complete treatment.
FAQ
Q. Can I combine Rejuran and Juvelook?
Yes. Some protocols alternate between the two across a treatment course. The specific combination and timing should be determined by your physician based on your skin assessment.
Q. Which is better for someone in their 20s vs. 40s?
In your 20s, Rejuran's barrier repair and pore improvement effects are often the most relevant. In your 40s, the collagen biostimulation of Juvelook or the tissue remodeling of Profhilo may be more valuable as skin density and laxity become primary concerns.
Q. Are skin boosters painful?
All three involve micro-injections into the dermis. Topical anesthetic is typically applied beforehand. Most patients describe it as manageable. Sensitivity varies by area — cheeks tend to be less sensitive than around the mouth or under the eyes.
Q. How long do results from Rejuran and Juvelook last?
Typically 3–6 months per session cycle, with maintenance sessions recommended. Results accumulate with regular treatments, meaning longevity increases with consistency.
Q. Is Rejuran safe for sensitive skin?
Rejuran is generally considered suitable for sensitive skin types. However, rare reactions to salmon-derived ingredients are possible. Always complete a medical consultation and disclose allergies beforehand.
Oganacell Dermatology Clinic (Magok) offers Rejuran (PN), Juvelook, and other skin boosters, all administered by a board-certified dermatologist. Prices published upfront. 10 minutes from Gimpo Airport, 5 minutes walk from Magok-Naru Station.
For questions or to book: WhatsApp, LINE (ogana_mg), or +82-2-2659-2888.